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Efficacy and safety of once-weekly cagrilintide for weight management: a randomised, placebo and active-controlled, dose-finding phase 2 trial Summary: This Phase 2 dose-finding trial investigated the efficacy and safety of cagrilintide monotherapy for weight management

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However, the patients enrolled in EMPA-REG had little CKD at the start of the trial

By lowering plasma glucose through renal excretion and modestly increasing circulating ketone availability, SGLT2 inhibitors shift systemic and cerebral energy metabolism away from exclusive dependence on glucose [27]